Process analytical technology as in-process control tool in semi-continuous manufacturing of PLGA/PEG-PLGA microspheres
Nowadays, among 3rd generation drug delivery systems, biodegradable polymeric based long-acting injectable depot has achieved tremendous success in clinical application.So far, there have been two dozen of commercial products of Poly (lactic-co-glycolic acid) microspheres available in the market.Recently, continuous manufacturing concept has been s